This work describes the concept of bond order. It shows that covalent bond energy is correlated to bond order. Simple expressions which included bond order are introduced to calculate bond energies of homo-nuclear and hetero-nuclear bonds. Calculated values of bond energies are compared with literature values and show there is very good agreement between and calculated and experimental values in the vast majority of cases. Bond order reveals the strength of a bond and shows the number of bonds in both (...) homo-nuclear and hetero-nuclear covalent bonds. (shrink)

The classic, influential essay in 'descriptive metaphysics' by the distinguished English philosopher.

All developed human beings possess a practical mastery of a vast range of concepts, including such basic structural notions as those of identity, truth, existence, material objects, mental states, space, and time; but a practical mastery does not entail theoretical understanding. It is that understanding which philosophy seeks to achieve. In this book, one of the most distinguished of living philosophers, assuming no previous knowledge of the subject on the part of the reader, sets out to explain and illustrate a (...) certain conception of the nature of analytical philosophy. Strawson draws on his many years of teaching at Oxford University, during which he refined and developed what he regards as the most productive route to understanding the fundamental structure of human thinking. Among the distinctive features of his exposition are the displacement of an older, reductive conception of philosophical method in favor of elucidating the interconnections between the complex but irreducible notions which form the basic structure of our thinking; and the demonstration that the three traditionally distinguished departments of metaphysics, epistemology, and logic are but three aspects of one unified enquiry. Strawson has produced an elegant work that will be invaluable to students and stimulating for professional philosophers and general readers alike. (shrink)

The species-specific organizational property of speech is a continual mouth open-close alternation, the two phases of which are subject to continual articulatory modulation. The cycle constitutes the syllable, and the open and closed phases are segments framescontent displays that are prominent in many nonhuman primates. The new role of Broca's area and its surround in human vocal communication may have derived from its evolutionary history as the main cortical center for the control of ingestive processes. The frame and content components (...) of speech may have subsequently evolved separate realizations within two general purpose primate motor control systems: (1) a motivation-related medial system, including anterior cingulate cortex and the supplementary motor area, for self-generated behavior, formerly responsible for ancestral vocalization control and now also responsible for frames, and (2) a lateral system, including Broca's area and surround, and Wernicke's area, specialized for response to external input (and therefore the emergent vocal learning capacity) and more responsible for content. (shrink)

An action-oriented perspective changes the role of an individual from a passive observer to an actively engaged agent interacting in a closed loop with the world as well as with others. Cognition exists to serve action within a landscape that contains both. This chapter surveys this landscape and addresses the status of the pragmatic turn. Its potential influence on science and the study of cognition are considered (including perception, social cognition, social interaction, sensorimotor entrainment, and language acquisition) and its impact (...) on how neuroscience is studied is also investigated (with the notion that brains do not passively build models, but instead support the guidance of action). A review of its implications in robotics and engineering includes a discussion of the application of enactive control principles to couple action and perception in robotics as well as the conceptualization of system design in a more holistic, less modular manner. Practical applications that can impact the human condition are reviewed (e.g., educational applications, treatment possibilities for developmental and psychopathological disorders, the development of neural prostheses). All of this foreshadows the potential societal implications of the pragmatic turn. The chapter concludes that an action-oriented approach emphasizes a continuum of interaction between technical aspects of cognitive systems and robotics, biology, psychology, the social sciences, and the humanities, where the individual is part of a grounded cultural system. (shrink)

Among the objections to the implementation of what I will call "genome editing in human reproduction" is that it does not address any unmet medical need, and therefore fails to meet an important criterion for introducing an unproven procedure with potentially adverse consequences. To be clear: what I mean by GEHR is the use of any one of a number of related biological techniques, such as the CRISPR-Cas9 system, deliberately to modify a functional sequence of DNA in a cell of (...) a human embryo, so that the modified sequence is replicated in the cells of a resulting child and may, without further intervention, be passed on to that child's biological descendants. It is... (shrink)

Current diagnostic criteria for schizophrenia place emphasis on delusions and hallucinations, whereas the classical descriptions of schizophrenia by Kraepelin and Bleuler emphasized disorganization and impoverishment of mental activity. Despite the availability of antipsychotic medication for treating delusions and hallucinations, many patients continue to experience persisting disability. Improving treatment requires a better understanding of the processes leading to persisting disability. We recently introduced the term classical schizophrenia to describe cases with disorganized and impoverished mental activity, cognitive impairment and predisposition to persisting (...) disability. Recent evidence reveals that a polygenic score indicating risk for schizophrenia predicts severity of the features of classical schizophrenia: disorganization, and to a lesser extent, impoverishment of mental activity and cognitive impairment. Current understanding of brain function attributes a cardinal role to predictive coding: the process of generating models of the world that are successively updated in light of confirmation or contradiction by subsequent sensory information. It has been proposed that abnormalities of these predictive processes account for delusions and hallucinations. Here we examine the evidence provided by electrophysiology and fMRI indicating that imprecise predictive coding is the core pathological process in classical schizophrenia, accounting for disorganization, psychomotor poverty and cognitive impairment. Functional imaging reveals aberrant brain activity at network hubs engaged during encoding of predictions. We discuss the possibility that frequent prediction errors might promote excess release of the neurotransmitter, dopamine, thereby accounting for the occurrence of episodes of florid psychotic symptoms including delusions and hallucinations in classical schizophrenia. While the predictive coding hypotheses partially accounts for the time-course of classical schizophrenia, the overall body of evidence indicates that environmental factors also contribute. We discuss the evidence that chronic inflammation is a mechanism that might link diverse genetic and environmental etiological factors, and contribute to the proposed imprecision of predictive coding. (shrink)

This paper examines how people in West Africa are reacting to the Ebola virus disease, an epidemic presently prevalent in the region. Certain lifestyle changes are suggested. Additionally, the heart of the paper focuses on the request by governments to be allowed access to experimental drugs, such as Zmapp and TKM-Ebola, for their infected populations. The author argues that granting such a request would circumvent research ethics procedures, which could potentially constitute significant risk to users of the drugs. The Pfizer (...) Kano meningitis trial of 1996 is cited as an example to buttress how unapproved drugs could prove fatal. (shrink)

I expressed agreement with Unger's view of the essential\nnature of personal identity, but dissented from what I took\nto be his view of the value we attach to its preservation;\nsaying, for example, that, in common, I think with many\nothers, I would prefer being replaced or succeeded' by a\nnumerically distinct continuator' with "qualitatively"\nidentical memories and mental and physical characteristics\nto surviving as the "numerically" identical person with\nsevere impairment of memory and abilities.

Henry David Thoreau, though often characterised as individualist or apolitical, is in fact an important link between Jeffersonian agrarian republicanism and environmentalism. Like the Jeffersonians, Thoreau espouses a political economy of citizenship, criticises modern capitalism, and celebrates simplicity and personal independence. However, Thoreau rejects the Jeffersonians' focus on conquest of the wilderness and economic industriousness, both of which were meant to promote virtue. Thoreau advocates preservation of wild nature as essential for cultivating virtue and regards nature as a community deserving (...) respect and protection. He criticises an emphasis on economic industriousness as promoting overwork, environmental destruction and greed. Thoreau emerges as a complex figure whose legacy points in two contrasting directions: toward a more ecologically responsible or sustainable republicanism embracing preservation of a spectrum of landscapes from wilderness to agrarian, and also toward a problematic, depoliticising separation between human beings and nature. (shrink)

Dans cet article, l'A. nous propose une solution à un vexant problème théologique, à savoir la façon dont la vision béatifique complète la nature humaine tout en demeurant un don au delà du don divin qui est notre être naturel. En se penchant sur l'oeuvre de Thomas d'Aquin, Ryan encadre d'abord le problème. Ensuite il étudie l'émergence de la théorie dite de «pure nature» comme réponse à Baius, lequel affirmait qu'avant la chute d'Adam la vision béatifique n'était que le complément, (...) dû nécessairement à la nature humaine. L'auteur nous présente également la défense offerte par Garrigou-Lagrange de la théorie de «pure nature», ainsi que la critique offerte par de Lubac. Nous remarquons effectivement que la prise de position des partisans de «pure nature» et celle adoptée par de Lubac se réfutent mutuellement. Ensuite nous étudions la position de Rahner. Selon Ryan, l'apport de Rahner est important; cependant une solution basée sur «l'existentiel surnaturel» rahnerien reste intenable. En fin de compte, l'auteur nous propose une solution qui tire profit de ces points de vue divergents, tout en évitant les pièges qui les accompagnent. (shrink)

Thomas d'Aquin pense que tout homme dirige nécessairement toutes ses actions vers une fin ultime unique. L'article rejette cette position et son présupposé que tout homme cherche nécessairement une béatitude parfaite qui ne laisse rien à désirer. L'article affirme au contraire que les hommes agissent souvent de façon simultanée en vue de plus d'une fin dernière. Ceux qui pèchent mortellement le font en commettant des actions gravement mauvaises, tout en croyant et espérant en Dieu. Ceux qui vivent dans la grace (...) sont supposés avoir Dieu pour leur fin derniere unique. Cependant, tout péché véniel délibéré est commis pour une autre fin ultime. En fait, les gens posent souvent des actions moralement bonnes pour une fin ultime autre que Dieu, car la foi vivante n'informe pas automatiquement toute la vie. On doit apprendre à chercher d'abord le Royaume de Dieu, conçu comme incluant non seulement le bien infini mais aussi les biens créés dans lesquels les coeurs inquiets des hommes trouvent leur accomplissement intégral. (shrink)

The Frame/Content theory deals with how and why the first language evolved the present-day speech mode of programming syllable “Frame” structures with segmental “Content” elements. The first words are considered, for biomechanical reasons, to have had the simple syllable frame structures of pre-speech babbling, and were perhaps parental terms, generated within the parent–infant dyad. Although all gestural origins theories have iconicity as a plausible alternative hypothesis for the origin of the meaning-signal link for words, they all share the problems of (...) how and why a fully fledged sign language, necessarily involving a structured phonology, changed to a spoken language. (shrink)

We endorse Davey's view that expectancy processes are intimately involved in fear reactions, but question his model on three grounds. First, the mechanism for generating expectancy bias to both ontogenetic and phylogenetic stimuli is not spelled out. Second, the selective association component is unnecessary. Third, the model fails to provide a clear explanation for the irrationality of phobic reactions.

Words denoting “mother” in baby talk and in languages usually include nasal sounds, supporting Falk's suggestion that infant nasalized demand vocalizations might have motivated a first word. The linguistic contrast between maternal terms and paternal terms, which favor oral consonants, and the simple phonetic patterns of parental terms in both baby talk and languages also suggest parental terms could have been first words.